Jan 20, 2017 · Researchers wanted to see whether combining alpha-blockers with anticholinergics as an initial therapy for enlarged prostate was more effective than administering alpha blockers first, then adding anticholinergics — a process known as add-on therapy. Alpha-blockers are a large family of therapies that block α1-adrenergic receptors in May 28, 2023 · Purpose We aimed to outline the existing information and the underlying mechanisms of risk of falls associated with the use of urinary antimuscarinics for overactive bladder (OAB) or alpha-blockers for benign prostatic hyperplasia (BPH) in older adults. In addition, we aimed to provide assistance to clinicians in decision-making about (de-)prescribing these drugs in older adults. Methodology Another troubling side effect of alpha-blockers is the development of ejaculatory dysfunction (up to 16% of patients will experience this). In a study of over 2,000 BPH patients, a maximum of 10 mg of terazosin reduced average AUA Symptom Index scores from 20 to 12.4 over one year, compared to a drop from 20 to 16.3 in patients taking a placebo. Aug 8, 2022 · Benign prostatic hyperplasia (BPH) refers to the nonmalignant growth or hyperplasia of prostate tissue and is a common cause of lower urinary tract symptoms in men. Disease prevalence has been shown to increase with advancing age. Indeed the histological prevalence of BPH at autopsy is as high as 50% to 60% for males in their 60's, increasing to 80% to 90% of those over 70 years of age.[1] Sep 2, 2021 · In this sub-cohort 26.9% of patients received combination therapy including any alpha-blocker and any antimuscarinic agent and 2.6% received any alpha-blocker plus mirabegron. Furthermore, 7.7% of this sub-cohort received triple therapy with any alpha-blocker plus any 5-ARI plus any OAB drug (Table 3). Treatment options include 5 alpha-reductase inhibitors, alpha-blockers, tadalafil, and surgery. Using the criteria of a prostate volume > 30 mL and a moderate or high American Urological Association Symptom Score (see table American Urological Association Symptom Score for Benign Prostatic Hyperplasia ), the prevalence of BPH in men aged 55 to Oct 18, 2021 · Alpha blocker treatment is established and proven to be the most effective course of treatment for BPH patients, but ongoing research shows greater potential when combined with DHT medication¹. These treatments can take up to four years to complete; they safely reduce prostate sizes by up to a quarter and typically achieve symptomatic relief Mar 3, 2021 · The data set Siemens and colleagues studied included 8339 BPH patients exposed to 5-alpha reductase inhibitors, 55,383 exposed to alpha blockers, and 41,491 who had taken a combination. Cardiac failure risk was an average 22% higher among those exposed to alpha blockers alone; 16% higher on combination; and 9% higher among men exposed to 5 Mar 1, 2008 · In men with benign prostatic hyperplasia, initiation of treatment with alpha blockers at the time of catheter insertion improves the success rate of trial of voiding without catheter. B 36 , 37 Jan 8, 2018 · The alpha-1 adrenergic receptor antagonists (also called alpha-blockers) are a family of agents that bind to and inhibit type 1 alpha-adrenergic receptors and thus inhibit smooth muscle contraction. Their major uses are for hypertension and for symptomatic benign prostatic hypertrophy. Their use in therapy of hypertension is based on the inhibition of vascular resistance in arterioles from JuvdsA.